Whether the music is orchestral, rock, country, or jazz, most seniors like to listen to some kind of music. Music can soothe or energize, make us happy or sad, but the kind we like to hear does something that can be positively reinforcing or otherwise we would not listen to it. As my 80-year-old jazz trumpeter friend, Richard Phelps, recently said at his birthday party, "Where there is life there is music. Where there is music, there is life."

Relatively little research has been done on the effects of music on brain function in older people. But one study recently reported the effects in older adults of background music on brain processing speed and two kinds of memory (episodic and semantic). The subjects were not musicians and had an average age of 69 years.

The music test conditions were: 1) no music control, 2) white noise control, 3) a Mozart recording, and 4) a Mahler recording. All 65 subjects were tested in counter-balanced order in all four categories. The music was played at modest volume as background before and during performance of the cognitive tasks, a mental processing speed task and the two memory tasks. The episodic memory task involved trying to recall a list of 15 words immediately after a two-minute study period. The semantic memory task involved word fluency in which subjects wrote as many words as they could think of beginning with three letters of the alphabet.

Processing speed performance was faster while listening to Mozart than with the Mahler or white noise conditions. No improvement in the Mahler condition was seen over white noise or no music.

Episodic memory performance was better when listening to either type of music thatn while hearing white noise or no music. No difference was noted between the two types of music.

Semantic memory was better for both kinds of music than with white noise and better with Mozart that with no music.

Recognizing that emotions could be a relevant factor, the experimenters analyzed a mood questionnaire comparing the two music conditions with white noise. Mozart generated higher happiness indicators than did Mahler or white noise. Mahler was rated more sad than Mozart and comparable to white noise.

Thus, happy, but not sad, music correlated with increased processing speed. The researchers speculated that happy subjects were more around and alert.

Surprisingly, both happy and sad music enhanced both kinds of memory over the white noise or silence condition. But it is not clear if this observation is generally applicable. The authors did mention without emphasis that the both kinds of music were instrumental and lacked loudness or lyrics that could have been distracting and thus impair memory. I think this point is substantial. When lyrics are present, the brain is dragged into trying to hear the words and thinking about their meaning. These thought processes would surely interfere with trying to memorize new information or recall previous learned material.

A point not considered at all is personal preference for a certain types of music. There are people who don't like classical music, and the data in this study could have been made "noisy" if enough of the 65 people disliked classical music and were actually distracted by it. In other words, the effects noted in this study might have been magnified if the subjects were allowed to hear their preferred music.

My take-home lesson was actually formed over five decades ago when I listed to jazz records while plowing my way through memorizing a veterinary medical curriculum. Then, I thought that the benefit was stress reduction (veterinary school IS stressful and happy jazz certainly reduces stress). Now perhaps I see that frequent listening to music that was pleasurable for me might have actually helped my memory capability. If you still have doubts you might want to check my latest blog post, "Happy thoughts can make you more competent" (http://thankyoubrain.blogspot.com/2015/01/happy-thoughts-can-make-you-more.html).

Anyway, now that I am in the elderly category, I see there is still reason to listen to the music I like. Music can be therapy for old age.

“People haven't always been there for me but music always has.”

    —Taylor Swift

"Memory Medic's" latest book is "Improve Your Memory for a Healthy Brain. Memory Is the Canary in Your Brain's Coal Mine." It is available in inexpensive e-book form at Amazon or in all formats at Smashwords.com.

Source:

Bottiroli, Sara et al. (2014). The cognitive effects of listening to background music on older adults: processing speed improves with upbeat music, while memory seems to benefit from both upbeat and downbeat music. Frontiers in Aging Neuroscience. Oct. 15. doi: 10.3389/fnagi.2014.00284.

Joe: My doctor told me to give up drinking, smoking, and fatty foods.

Sam: What will you do?

Joe: I think I’ll give up my doctor.

I try not to get too excited about memory benefits of supplements, because too often the claims are not substantiated by studies that are well controlled and peer reviewed. I now think resveratrol may be one of the few supplements that benefits brain function.

When I wrote my first blog on research on resveratrol benefits for brain function and memory, there were over 2,000 scientific papers.[1]Don't worry; I am only going to tell you about a few studies.

Resveratrol is an active ingredient in red wine. This compound has been credited for explaining why red-wine drinkers in France, who drink more wine than most people, are healthier than would be predicted by their lifestyle of little exercise and eating lots of cheese. The problem is most studies suggest you would have to drink a 100 or more glasses of red wine a day to get much resveratrol effect (and that effect would obviously be negated by a toxic dose of alcohol). An obviously more healthful choice is the highly concentrated pill forms of resveratrol that are now on the market.

Most of the protective biological actions associated with resveratrol have been associated with its scavenger properties for free radicals and the protective effects that it confers on the heart and diabetes. 

One important study comes from a diabetes research group in Brazil recently who reported a beneficial effect of resveratrol on diabetic rats.[2]Resveratrol (in a modest rat dose of 10 and 20 mg per kilogram per day for 30 days) prevented the impairment of memory induced by diabetes. An earlier study by another group showed resveratrol improved glucose metabolism and promoted longevity in diabetic mice.

Another benefit of resveratrol is the anti-oxidant property. The brain produces more free-radical damage than other organs, and compared with other organs the brain has especially low levels of antioxidant defense enzymes. 

One recent study has revealed resveratrol had protective effects against brain damage caused by a chemical that kills acetylcholine neurons. Injection of this toxin into the brain of rats impaired their memory performance in two kinds of maze tasks. The impairment was significantly reduced by repeated injection of resveratrol (10 and 20 mg/kg) per day for 25 days, beginning four days before the toxin injection.[3]

Another recent study examined effects on working memory in mice fed a resveratrol-supplemented diet for four weeks before being injected with a cytokine to induce inflammation and accelerate aging. Resveratrol significantly reduced memory impairment in the aged group, but not in the young adults[4]. The lack of benefit in young adults was a little misleading, in that there was a "ceiling effect" in that the young adults were not impaired by the cytokine injection.

 The practical issue for us is whether resveratrol will help cognitive function in humans, especially healthy humans. It seems likely because other substances that have strong anti-oxidant properties seem to improve memory capability. Because animal studies have shown promise for resveratrol in preventing or treatment several different conditions associated with aging, several human clinical trials have been initiated.[5]

 An impressive new study of older humans, male and female, has just been reported.[6]Twenty-three healthy, but overweight people completed 6 months of daily resveratrol intake (200 mg ― the commercial brand I take has 300 mg/capsule). A paired control group got placebo pills. A double-blind design assured that neither the subjects nor the experimenters knew which individuals were in each group during data processing.

Memory tests of word recall revealed significant improvement in the resveratrol group. Resveratrol also increased brain-scan measures of functional connectivity, which identified  linked neural activity between the hippocampus and several areas of cerebral cortex.

Because others had shown that resveratrol increased insulin sensitivity in humans, these authors examine several markers important to diabetes. Resveratrol decreased the standing levels of sugar-bound hemoglobin, a standard marker for glucose control.  

What foods besides red grapes have resveratrol? The most likely other sources you would eat or drink are blueberries, cranberries, and peanuts. It is not likely that you could drink or eat enough of such substances to get enough resveratrol to do much good. Because of the scientifically documented benefits of resveratrol, highly concentrated supplements are now on the market (I have been taking it for a couple of years) I haven't given up my two glasses of red wine each day, but I have started taking one of the supplements. I haven't seen any reports that high doses of resveratrol are toxic.

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[1] http://thankyoubrain.blogspot.com/2010/04/resveratrol-red-wine-magic-chemical.htmlApril 4, 2010.

[2] Schmatz R, et al. (2009). Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2009 May 21;610(1-3):42-8. Epub 2009 Mar 19.

[3] Kumar, A. et al. 2007. Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Pharmacology.79 (1): 17-26. DOI: 10.1159/000097511

[4] Abraham, J., and Johnson, R. W. 2009. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation research. 12 (6): 445-453.  DOI: 10.1089/rej.2009.0888

[5]Smoliga, J. M. et al. (2011). Resveratrol and health – a comprehensive review of human clinical trials. Mol. Nutrition Food Res. 55: 1129-1141

[6] Witte, A. V., et al. (2014) Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J. Neuroscience. 34 23): 7862-7870.

I just attended a “Laughter is Good Medicine” seminar put on by a local hospital. The speaker pointed to evidence showing that laughing has such good effects as:

·         Reduce blood pressure

·         Lower blood glucose

·         Dull pain

·         Alleviate stress and anxiety

·         Improve feeling of well being

and it even burns substantial calories.

I suspect humor also improves longevity, though I only have anecdotal and presumptive evidence for that. But the evidence seems hard to dismiss. Think about how long so many classic stand-up comedians of the

preceding generation lived.

Most of these comedians were actively performing right up to their last days. Here is a listing of comedians most people in my generation will recognize and their age when they finally died.

Bob Hope, 100

George Burns, 100

Phyllis Diller, 95

Milton Berle, 94

Henny Youngman, 92

Victor Borge, 91

Dick Van Dyke, 88 (still alive)

Jimmy Durante, 87

Jerry Lewis, 87 (still performing)

Bea Arthur, 87

Groucho Marx, 87

Jonathan Winters, 86

Jack Paar, 86

Red Skelton, 84

Bob Newhart, 84 (still performing)

Soupy Sales, 83

Rodney Dangerfield, 83

Mel Blanc, 81

Johnny Carson, 80

Jack Benny, 80

These comedians obviously had good memories, because even in their old age they could spout a steady stream of jokes from memory without a teleprompter. To have a good memory, you have to have a healthy brain, and a healthy brain often is healthy because the body is healthy. Healthy bodies live longer.

Let’s also remember that some of these people led a hard life, mostly on the road, in an era when people in general did not live that long.

One thing is for sure. Whether or not humor makes you live longer, it surely does make you live happier.

In an earlier post, I reviewed research showing that seniors compensate for any loss of memory ability by having developed learning and memory schemas over the years. Such schemas are ingrained strategies and ways of efficient learning that improve with experience and age.

Now I have come across recent research that shows another age-developed skill: improved decision-making ability. Teenagers are notorious for poor decision-making. Of course that is inevitable, given that their brains are still developing and they have had relatively little life experience to show them what works and what doesn’t. Unfortunately, what doesn’t work often has more emotional appeal, and most of us at any age are more susceptible to our emotions than to cold, hard logic.

Seniors also are prone to poor decision-making if senility has set it. Unscrupulous people take advantage of such seniors because a brain that is deteriorating has a hard time making wise decisions.

In between teenage and senility is when the brain is at its peak for good decision making, especially improving as one gets older. Some Eastern cultures venerate their older people as generally being especially wise. After all, it you live long enough, and are still mentally healthy, you ought to make good decisions because you have a lifetime of experience to teach you what future choices are likely to work and which are not.

Much of that knowledge comes from learning from one’s mistakes. On the other hand, some people, especially the young, can’t seem to learn from their mistakes. In any case, the best strategy of all is to learn from somebody else’s mistakes so you don’t have to make them yourself.

Learning from your mistakes can be negative if you fret about it. Learning what you can to avoiding repeating a mistake is one thing, but dwelling on it erodes one’s confidence and sense of self worth. I can never forget the good advice I read recently from, of all people, T. Boone Pickens, who has lost and regained fortunes several times. He was quoted in an interview as saying that he was able to re-make his fortune on multiple occasions because he didn’t dwell on the failures. He credited that attitude to his Oklahoma State basketball coach, who told the team after each defeat, “Learn from your mistakes, but don’t dwell on them. Learn from what you did right and do more of that.”

A key reason seniors make better decisions is that they have a richer store of knowledge and experience. Any choice among alternative options is affected by how much information for each option the brain has to work on. When the brain is consciously trying to make a decision, this often means how much information the brain can hold in working memory. Working memory is notoriously low-capacity, so the key becomes remembering the sub-sets of information that are the most relevant to each option. People are more likely to remember items they value and to forget low-value items.[1]

It turns out, apparently, that older people are more likely to remember the most useful information and thus make better conclusions and decisions. The National Institute of Aging began funding decision-making research in 2010 at Stanford University’s Center on Longevity. Results of their research are showing how older people often make better decisions than younger people.[2]^,[3]

As one example, older people are more likely to make rational cost-benefit analyses. Older people are more likely to recognize when they have made a bad investment and walk away rather than throwing more good money after bad.

A key factor seems to be that older people are more selective about what they remember. For example, one study from the Stanford Center compared the ability of young and old people to remember a list of words. Not surprisingly, younger people remembered more words, but when words were assigned a number value, with some words being more valuable than others, older people were better at remembering high-value words and ignoring low-value words. It may be that older people selectively remember what is important, which could explain why they make better decisions.

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[1] Castel, A. D., Rhodes, M. G., McCabe, D. P., Soderstrom, N. C., Loaiza, V. M. (2012). The fate of being forgotten: Information that is initially forgotten is judged as less important. Quarterly Journal of Experimental Psychology, 65, 2281-2287.

[2] Samanez-Larkin, G.R., Wagner, A.D., Knutson, B. (2011) Expected value information improves financial risk taking across the adult life span. Social Cognitive and Affective Neuroscience, 6(2), 207–217

[3]Carr, Dawn (2013). Why older minds make better decisions. Forbes. http://www.forbes.com/sites/nextavenue/2013/04/29/why-older-minds-make-better-decisions/

For more good advice on improving learning and memory abilities, see Dr. Klemm’s new book, Memory Power 101, Skyhorse Publishing.

Snore a lot? Get up frequently at night to urinate? Wake up at 2 A.M. with bright ideas or worries? All these disruptions of sleep are common and more so as we get older. Does it matter? Well, of course such awakenings disrupt our sleep, and maybe it is just inconvenient. But disrupted sleep not only is more likely with age, it may promote deterioration in mental functioning. A recent study compared the effects of sleeping behavior in young adults and seniors. The study involved assessing the memory after sleeping of 18 young adults in their 20s and 15 older adults in their 70s. The subjects were tested on 120 word sets before they went to bed, and an EEG machine monitored their brain activity while they slept. Upon awakening, they were tested once again on the word pairs, but this time they took the tests while undergoing functional  magnetic resonance imaging (fMRI) scans.

The quality of deep sleep among the older adults was 75 percent lower than the younger ones, and their memory was significantly worse the next day−55 percent worse. The scans suggested deterioration of the frontal lobe. Shrunken brains can occur from aging and shrunken brains impair thinking and memory. But is it possible we have the cause and the effect backwards. Maybe what happens in the environment, such as impaired sleeping, causes both the shrunken brain and the impaired memory. Or in other words, what causes older brains to shrink?

Scientists consider a decrease of about 2% shrinkage every 10 years as normal. That may not be normal, just what most people experience because they are not taking care of their brains. There is abundant research that shows that exercises for both the brain and body help to reduce brain atrophy.

Of course, anything that damages neurons can reduce the number of their tree-like processes and the density of their contact points with other neurons. The list of such causes is long, including: alcohol abuse, brain inflammation, certain infections, concussion, impaired blood supply, lack of intellectual stimulus, vitamin B12 deficiency. It now appears that we should add fragmented sleep to the list.

Common natural causes of fragmented sleep in older humans are alcohol abuse and sleep apnea. Also, in males, enlarged prostate causes a need for frequent urination. As I have explained in my learning and memory blog posts (thankyoubrain.blogspot.com), learning events during the day are consolidated into lasting form during the sleep at night of the same day. We don’t know exactly how sleep helps, but obviously, you have far fewer mental distractions during sleep — unless, of course you keep waking up.

Alzheimer’s Disease also causes fragmented sleep. So, it is no surprise that the brain degeneration by the disease would cause memory problems. But maybe, just maybe, it is the fragmented sleep that accelerates onset of Alzheimer’s disease. Now, this seemingly ridiculous possibility has to be taken seriously in light of new research showing that sleep-disordered breathing, as in sleep apnea, seems to increase the risk of mental decline and even dementia in older women.

Disrupted sleep may also accelerate normal aging. This is certainly true when the cause is sleep apnea, which raises blood pressure and increases the cardiovascular damage that high blood pressure causes. Blood clotting is promoted, increasing the likelihood of strokes. Obesity and diabetes are often associated with sleep apnea, and it seems that sleep apnea not only results from obesity but can promote obesity and the diabetes that often accompanies obesity. Diabetes is toxic for nerve terminals. Similar neuropathy may also be occurring in their brain. Sleep apnea causes daytime sleepiness, and that it turn reduces attentiveness and mental activity, which when sustained over many years reduces the mental stimulus and promotes atrophy of neuronal processes.

Obviously, blood oxygen drops during sleep apnea. Normally, blood is 94% to 98% saturated with oxygen. But not breathing for 30 seconds or more during sleep causes oxygen level to drop to 80% or less. Any level below 90% oxygen level is dangerous, especially to the brain which demands nearly 20% of all the body’s oxygen supply. The adult brain can only survive about four minutes once oxygen is completely cut off.

So it is entirely possible that the slipping memory we see in so many elderly is a warning sign of something much more serious. But by the time the memory deficits show up, much of the damage has already been done. Prevention is the best hope.

Source:

Mander, B. A., Rao, V.,  Brandon, B. L., Saletin, J. M.,  et al. (2013). Prefrontal atrophy, disrupted NREM slow waves and impaired hippocampal-dependent memory in aging. Nature Neuroscience  doi:10.1038/nn.3324 

http://www.livestrong.com/article/161959-what-are-the-causes-of-brain-atrophy/

Yaffe, K., Laffan, A. M., Harrison, S. L. et al. (2011). Sleep-disordered breathing, hyupoxia, and risk of mild cognitive impairment and dementia in older women. JAMA. 306(6), 613-619. doi:10.1001/jama.2011.1115

For those who want to learn more about the brain, Dr. Klemm has just released the second edition of his e-book, “Core Ideas in Neuroscience.” See http://thankyoubrain.com/neurobook/index.htm