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Want to become an expert? It doesn’t matter what the subject is, the principle for developing expertise is the same. My many years of person...

Want to become an expert? It doesn’t matter what the subject is, the principle for developing expertise is the same. My many years of personal experience and observing students convinces me of a learning axiom: the more you know, the more you can know.
A recent research report helps to explain what the brain is doing as it acquires expertise. By observing which brain areas are active at the same time, one can conclude that such areas are probably functionally connected even though they are located at different locations within the brain’s network of circuits. In recently reported experiments, researchers used MRI scans of subjects as they rested after mastering a set of initial associations of pairs of faces and objects and as they learned new pairs. Scans were collected during rest immediately after subjects had memorized a series of face/object pairs, and during learning of new face/object pairs or pairs that did not overlap the original paired set. The data indicated that spontaneous activation of hippocampal and neocortical functional connectivity during rest was related to better subsequent learning of new pairs. Moreover, the degree of functional connectivity during rest predicted the brain-area functional connectivity activation during the new learning experience.
The rationale for the experiment includes the well-known fact that the hippocampus is needed to promote storage of explicit memories in the neocortex. Moreover, we know that “off-line” rehearsal of memories occurs during mental rest and even sleep because the participating neural circuitry becomes periodically reactivated. The issue that the researchers pursued was based on an assumption that one purpose of memory is to enhance the learning of future related material. Thus, the hippocampal-neocortex connectivity that occurred during initial learning should also recur during rest and be relevant to new related material.
Spontaneous activation of the hippocampal-neocortical functional connectivity in MRI scans is the index of this off-line memory processing. The data showing the relationship of this connectivity during rest and new learning support the author’s general conclusion that “how our brains capture and store new information is heavily influenced by what we already know.”
This brings me to the real practical relevance of this research: learning to learn. What we see here is scientific evidence for how the brain teaches itself by learning to have more learning.
Here is a practical example of what I mean. I just finished attending the Newport Jazz festival, which included interview of some of the artists. Jon Faddis, a phenomenal trumpet player who can begin a phrase with high C and go up from there, discussed his experience with his trainees. He tells them what most of them won’t do: “If you are not practicing 4-6 hours a day, every day, you are just wasting your time.”  In other words, to become an expert jazz musician, you have to accumulate a large amount of prior knowledge, which of course takes lots practice. I have noticed in my own career that over time I am getting more and more competent to move into new areas of neuroscience even though I am getting older and supposedly have less ability to learn than when I was young.
This brings me to the subject of education. Our educational system is crippled by the apparent assumption that children are good learners because their brains are young. Therefore, curriculum focuses on content and testing. But children don’t have much knowledge to build on to accomplish efficient learning of new content. To compensate, schools need much more emphasis on teaching basic learning skills, which children don’t know much about either, because again they don’t have much experience at learning how to learn. I'm not sure that teachers get enough training for teaching learning skills. 
Just what are these skills that I think should be taught explicitly in the early grades? I am writing a book on that to help parents and teachers. Here, I can only summarize. Learning skills operate in a cycle that begins with motivation–and yes, that is something you can learn, especially grit. Then comes learning how to be attentive and to focus. Next is knowing how to organize learning material coherently to make it easier to master. Material to be learned needs to be understood, not just memorized. There are multiple tactics one can learn to improve the ability to understand complex material. The better you understand a subject, the less you have to memorize because there is so much that you can acquire through reasoning. Memorization skills, however, are far more useful than most teachers realize or know how to teach. Most under-performance of students on high-stakes tests is due to poor memory, which is why teachers go over and over ad nauseum the same material in preparation for tests. The final steps in the learning skills cycle are problem solving and creativity. And yes, both of those skills are teachable for those who know how.
Regardless of subject matter, the process of acquiring enough knowledge to set the stage to become an expert includes also the implicit learning of how to learn new material in the field. There are no shortcuts to becoming an expert. The process begins with learning how to learn.

Dr. Klemm, a.k.a. “Memory Medic,” teaches teachers about the learning skills cycle. See his recent books, “Memory Power 101” and “Better Grades, Less Effort.”

Source:
Schlichting, Margaret L., and Preston, Alison R. (2015). Memory reactivation during rest supports upcoming learning of related content. Proc. Nat. Acad. Science, www.pnas.org/cgi/doi/10.1073/pnas.1404396111


Joe: My doctor told me to give up drinking, smoking, and fatty foods. Sam: What will you do? Joe: I think I’ll give up my doctor. I try not...

Joe: My doctor told me to give up drinking, smoking, and fatty foods.
Sam: What will you do?
Joe: I think I’ll give up my doctor.

I try not to get too excited about memory benefits of supplements, because too often the claims are not substantiated by studies that are well controlled and peer reviewed. I now think resveratrol may be one of the few supplements that benefits brain function.

When I wrote my first blog on research on resveratrol benefits for brain function and memory, there were over 2,000 scientific papers.[1]Don't worry; I am only going to tell you about a few studies.

Resveratrol is an active ingredient in red wine. This compound has been credited for explaining why red-wine drinkers in France, who drink more wine than most people, are healthier than would be predicted by their lifestyle of little exercise and eating lots of cheese. The problem is most studies suggest you would have to drink a 100 or more glasses of red wine a day to get much resveratrol effect (and that effect would obviously be negated by a toxic dose of alcohol). An obviously more healthful choice is the highly concentrated pill forms of resveratrol that are now on the market.

Most of the protective biological actions associated with resveratrol have been associated with its scavenger properties for free radicals and the protective effects that it confers on the heart and diabetes. 

One important study comes from a diabetes research group in Brazil recently who reported a beneficial effect of resveratrol on diabetic rats.[2]Resveratrol (in a modest rat dose of 10 and 20 mg per kilogram per day for 30 days) prevented the impairment of memory induced by diabetes. An earlier study by another group showed resveratrol improved glucose metabolism and promoted longevity in diabetic mice.

Another benefit of resveratrol is the anti-oxidant property. The brain produces more free-radical damage than other organs, and compared with other organs the brain has especially low levels of antioxidant defense enzymes. 

One recent study has revealed resveratrol had protective effects against brain damage caused by a chemical that kills acetylcholine neurons. Injection of this toxin into the brain of rats impaired their memory performance in two kinds of maze tasks. The impairment was significantly reduced by repeated injection of resveratrol (10 and 20 mg/kg) per day for 25 days, beginning four days before the toxin injection.[3]

Another recent study examined effects on working memory in mice fed a resveratrol-supplemented diet for four weeks before being injected with a cytokine to induce inflammation and accelerate aging. Resveratrol significantly reduced memory impairment in the aged group, but not in the young adults[4]. The lack of benefit in young adults was a little misleading, in that there was a "ceiling effect" in that the young adults were not impaired by the cytokine injection.

 The practical issue for us is whether resveratrol will help cognitive function in humans, especially healthy humans. It seems likely because other substances that have strong anti-oxidant properties seem to improve memory capability. Because animal studies have shown promise for resveratrol in preventing or treatment several different conditions associated with aging, several human clinical trials have been initiated.[5]

 An impressive new study of older humans, male and female, has just been reported.[6]Twenty-three healthy, but overweight people completed 6 months of daily resveratrol intake (200 mg ― the commercial brand I take has 300 mg/capsule). A paired control group got placebo pills. A double-blind design assured that neither the subjects nor the experimenters knew which individuals were in each group during data processing.

Memory tests of word recall revealed significant improvement in the resveratrol group. Resveratrol also increased brain-scan measures of functional connectivity, which identified  linked neural activity between the hippocampus and several areas of cerebral cortex.

Because others had shown that resveratrol increased insulin sensitivity in humans, these authors examine several markers important to diabetes. Resveratrol decreased the standing levels of sugar-bound hemoglobin, a standard marker for glucose control.  

What foods besides red grapes have resveratrol? The most likely other sources you would eat or drink are blueberries, cranberries, and peanuts. It is not likely that you could drink or eat enough of such substances to get enough resveratrol to do much good. Because of the scientifically documented benefits of resveratrol, highly concentrated supplements are now on the market (I have been taking it for a couple of years) I haven't given up my two glasses of red wine each day, but I have started taking one of the supplements. I haven't seen any reports that high doses of resveratrol are toxic.



[2] Schmatz R, et al. (2009). Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2009 May 21;610(1-3):42-8. Epub 2009 Mar 19.
[3] Kumar, A. et al. 2007. Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. Pharmacology.79 (1): 17-26. DOI: 10.1159/000097511
[4] Abraham, J., and Johnson, R. W. 2009. Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice. Rejuvenation research. 12 (6): 445-453.  DOI: 10.1089/rej.2009.0888
[5]Smoliga, J. M. et al. (2011). Resveratrol and health – a comprehensive review of human clinical trials. Mol. Nutrition Food Res. 55: 1129-1141
[6] Witte, A. V., et al. (2014) Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J. Neuroscience. 34 23): 7862-7870.